Keith Ferguson Megamind (voice) Laura Post Roxanne Ritchi (voice) Josh Brener OI' Chum (voice) Maya Tuttle Keiko Morita (voice) Emily Tuñon Lady Doppler (voice) Talon Warburton Lord Nighty-Knight (voice) Scott Adsit Pierre Pressure (voice) Chris Sullivan Behemoth (voice) Tony Hale Mel / Mr. Donut / TV Announcer (voice) Adam Lambert Machiavillain (voice) Jeanine Mason Christina Christo / Hostess (voice) Michael Beattie Eccentric Eddie (voice) Eric Fogel Polly 227 (voice) Todd Haberkorn Big King Fish (voice) Joey Rudman Red Snapper (voice) Carlos Alazraqui Additional Voices (voice) Kimberly Brooks Additional Voices (voice)